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Shaban, H.* ; O'Connor, R.* ; Ovsepian, S.V. ; Dinan, T.G.* ; Cryan, J.F.* ; Schellekens, H.*

Electrophysiological approaches to unravel the neurobiological basis of appetite and satiety: Use of the multielectrode array as a screening strategy.

Drug Discov. Today 22, 31-42 (2017)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Hypothalamic neural circuits are recognised as primary sites of the neuromodulator effect of homeostatic food intake, whereas changes in ventral tegmental area (VTA), hippocampus and amygdala have been implicated in the hedonic, cognitive and emotional aspects of eating. Here, we discuss synaptic transmission and plasticity within brain circuits governing appetite and food intake behaviour, focusing on the metabolic hormones ghrelin and leptin. We discuss functional changes within these circuitries and critically assess the applicability of electrophysiological measurements using in vitro multielectrode array (MEA) systems to identify novel appetite modulators. Stringent validation of functional assays to screen neuroactive substrates is of crucial importance for the discovery of novel food intake modulators, with major implications for the nutraceutical food industry and drug development.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Electrophysiology ; Food Intake ; Ghrelin ; Hypothalamic Circuitry ; Leptin. ; Mesolimbic Reward System ; Multielectrode Array Recordings ; Neuroendocrine Factors ; Synaptic Transmission And Plasticity; Long-term Potentiation; Metabotropic Glutamate Receptors; Central-nervous-system; Hippocampal Synaptic Plasticity; Cultured Cortical Networks; Paired-pulse Facilitation; Energy-balance; Neuronal-activity; Food-intake; Arcuate Nucleus
ISSN (print) / ISBN 1359-6446
e-ISSN 1878-5832
Zeitschrift Drug discovery today
Quellenangaben Band: 22, Heft: 1, Seiten: 31-42 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Cambridge
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)