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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Structural and functional 3D mapping of skin tumours with non-invasive multispectral optoacoustic tomography.
Skin Res. Technol. 23, 221-226 (2017)
BACKGROUND: Recent advances in technology have enabled the development of various non-invasive skin imaging tools to aid real-time diagnosis of both benign and malignant skin tumours, minimizing the need for invasive skin biopsy. Multispectral optoacoustic tomography (MSOT) is a recently developed non-invasive imaging tool, which offers the unique capacity for high resolution three dimensional (3D) optical mapping of tissue by further delivering highly specific optical contrast from a depth of several millimetres to centimetres in living tissues. MSOT enables volumetric, spectroscopic differentiation of tissue, both in vivo and in real time, with and without the application of biomarker-specific probes, and is further able of providing spatial maps of skin chromophores, as well as underlying blood vasculature. METHODS: Three patients with suspicious skin tumours consented to have their lesions imaged with MSOT prior to excision. The histological findings and measurements were compared. RESULTS: We demonstrated the first in vivo clinical use of MSOT for 3D reconstruction of skin tumours in three patients with good histological correlation. CONCLUSION: Our findings confirm the potential benefit of the new imaging method in guiding surgical intervention to achieve a more precise excision with better clearance and lower relapse rates. It can also potentially help to shorten the duration of Mohs' micrographic surgery. Further large-scale studies are necessary to ensure correlation between MSOT and histology.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
3d Mapping ; Multispectral Optoacoustic Tomography ; Histopathology ; Imaging ; Skin Tumours; Confocal Microscopy; Diagnosis; Cancer; Dermatology
ISSN (print) / ISBN
0909-752X
e-ISSN
1600-0846
Zeitschrift
Skin Research and Technology
Quellenangaben
Band: 23,
Heft: 2,
Seiten: 221-226
Verlag
Wiley
Verlagsort
Oxford
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed