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Ma, X. ; van Phi, V.* ; Kimm, M.A.* ; Prakash, J. ; Kessler, H.* ; Kosanke, K.* ; Feuchtinger, A. ; Aichler, M. ; Gupta, A.* ; Rummeny, E.J.* ; Eisenblätter, M.* ; Siveke, J.* ; Walch, A.K. ; Braren, R.* ; Ntziachristos, V. ; Wildgruber, M.*

Integrin-targeted hybrid fluorescence molecular tomography/X-ray computed tomography for imaging tumor progression and early response in non-small cell lung cancer.

Neoplasia 19, 8-16 (2017)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Integrins play an important role in tumor progression, invasion and metastasis. Therefore we aimed to evaluate a preclinical imaging approach applying ανβ3 integrin targeted hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography (FMT-XCT) for monitoring tumor progression as well as early therapy response in a syngeneic murine Non-Small Cell Lung Cancer (NSCLC) model. Lewis Lung Carcinomas were grown orthotopically in C57BL/6 J mice and imaged in-vivo using a ανβ3 targeted near-infrared fluorescence (NIRF) probe. ανβ3-targeted FMT-XCT was able to track tumor progression. Cilengitide was able to substantially block the binding of the NIRF probe and suppress the imaging signal. Additionally mice were treated with an established chemotherapy regimen of Cisplatin and Bevacizumab or with a novel MEK inhibitor (Refametinib) for 2 weeks. While μCT revealed only a moderate slowdown of tumor growth, ανβ3 dependent signal decreased significantly compared to non-treated mice already at one week post treatment. ανβ3 targeted imaging might therefore become a promising tool for assessment of early therapy response in the future.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Alpha(v)beta(3) Expression; Alpha-v-beta-3 Integrin; Antiangiogenic Therapy; Phase-ii; Angiogenesis; Nanoparticles; Cilengitide; Mice; Rgd; Pet
ISSN (print) / ISBN 1522-8002
e-ISSN 1476-5586
Zeitschrift Neoplasia : An International Journal for Oncology Research
Quellenangaben Band: 19, Heft: 1, Seiten: 8-16 Artikelnummer: , Supplement: ,
Verlag Neoplasia Press
Verlagsort New York
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Research Unit Analytical Pathology (AAP)