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Wang, L.* ; Heckman, M.G.* ; Aasly, J.O.* ; Annesi, G.* ; Bozi, M.* ; Chung, S.J.* ; Clarke, C.* ; Crosiers, D.* ; Eckstein, G.N. ; Garraux, G.* ; Hadjigeorgiou, G.M.* ; Hattori, N.* ; Jeon, B.* ; Kim, Y.J.* ; Kubo, M.* ; Lesage, S.* ; Lin, J.J.* ; Lynch, T.* ; Lichtner, P. ; Mellick, G.D.* ; Mok, V.* ; Morrison, K.E.* ; Quattrone, A.* ; Satake, W.* ; Silburn, P.A.* ; Stefanis, L.* ; Stockton, J.D.* ; Tan, E.K.* ; Toda, T.* ; Brice, A.* ; van Broeckhoven, C.* ; Uitti, R.J.* ; Wirdefeldt, K.* ; Wszolek, Z.* ; Xiromerisiou, G.* ; Maraganore, D.M.* ; Gasser, T.* ; Kruger, R.* ; Farrer, M.J.* ; Ross, O.A.* ; Sharma, M.*

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: Analysis of a large multicenter study.

Neurobiol. Aging 49, 217.e1-217.e4 (2017)
Postprint Forschungsdaten DOI PMC
Open Access Green
A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Genetic Epidemiology ; Lrrk2 ; Park16 ; Parkinson's Disease
ISSN (print) / ISBN 0197-4580
e-ISSN 1558-1497
Zeitschrift Neurobiology of Aging
Quellenangaben Band: 49, Heft: , Seiten: 217.e1-217.e4 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort New York, NY [u.a.]
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)