Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mining protein lists from proteomics studies: Applications for drug discovery.
Expert Opin. Drug Discov. 5, 323-331 (2010)
Importance of the field: In recent years, proteomics has become a common technique applied to a wide spectrum of scientific problems, including the identification of diagnostic biomarkers, monitoring the effects of drug treatments or identification of chemical properties of a protein or a drug. Although being significantly different in scientific essence, the ultimate result of the majority of proteomics studies is a protein list. Thousands of independent proteomics studies have reported protein lists in various functional contexts. Areas covered in this review: We review here the spectrum of scientific problems where proteomics technology was applied recently to deliver protein lists. The available bioinformatics methods commonly used to understand the properties of the protein lists are compared. What the reader will gain: The types and common functional properties of the reported protein lists are discussed. The range of scientific problems where this knowledge could be potentially helpful with a focus on drug discovery issues is explored. Take home message: Reported protein lists represent a valuable resource which can be used for a variety of goals, ranging from biomarkers discovery to identification of novel therapeutic implications of known drugs.
Impact Factor
Scopus SNIP
Scopus
Cited By
Cited By
Altmetric
1.354
0.300
1
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
databases; gene list; PLIPS; protein list; proteomics; text mining
Sprache
englisch
Veröffentlichungsjahr
2010
HGF-Berichtsjahr
2010
ISSN (print) / ISBN
1746-0441
e-ISSN
1746-045X
Zeitschrift
Expert Opinion on Drug Discovery
Quellenangaben
Band: 5,
Heft: 4,
Seiten: 323-331
Verlag
Informa Healthcare
Verlagsort
London
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
G-503700-001
Scopus ID
77950281870
Erfassungsdatum
2010-12-31