PuSH - Publikationsserver des Helmholtz Zentrums München: Time-saving screening for diabetes in patients with coronary artery disease: A report from EUROASPIRE IV.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Gyberg, V.* ; de Bacquer, D.* ; Kotseva, K.* ; de Backer, G.* ; Schnell, O.* ; Tuomilehto, J.* ; Wood, D.L.* ; Rydén, L.*

Time-saving screening for diabetes in patients with coronary artery disease: A report from EUROASPIRE IV.

BMJ Open 6:e013835 (2016)

Verlagsversion

DOI

PMC

	Open Access Gold

Abstract
Metriken
Zusatzinfos

Background WHO advocates 2-hour oral glucose tolerance test (OGTT) for detecting diabetes mellitus (DM). OGTT is the most sensitive method to detect DM in patients with coronary artery disease (CAD). Considered time consuming, the use of OGTT is unsatisfactory. A 1-hour plasma glucose (1hPG) test has not been evaluated as an alternative in patients with CAD. Objectives To create an algorithm based on glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and 1hPG limiting the need of a 2-hour plasma glucose (2hPG) in patients with CAD. Methods 951 patients with CAD without DM underwent OGTT. A 2hPG≥11.1mmol/L was the reference for undiagnosed DM. The yield of HbA1c, FPG and 1hPG was compared with that of 2hPG. Results Mean FPG was 6.2±0.9mmol/L, and mean HbA1c 5.8±0.4%. Based on 2hPG≥11.1mmol/L 122 patients (13%) had DM. There was no value for the combination of HbA1c and FPG to rule out or in DM (HbA1c≥6.5%; FPG≥7.0mmol/L). In receiver operating characteristic analysis a 1hPG≥12mmol/L balanced sensitivity and specificity for detecting DM (both=82%; positive and negative predictive values 40% and 97%). A combination of FPG<6.5mmol/L and 1hPG<11mmol/L excluded 99% of DM. A combination of FPG>8.0mmol/L and 1hPG>15mmol/L identified 100% of patients with DM. Conclusions Based on its satisfactory accuracy to detect DM an algorithm is proposed for screening for DM in patients with CAD decreasing the need for a 2-hour OGTT by 71%.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

2.562

1.202