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Gyberg, V.* ; de Bacquer, D.* ; Kotseva, K.* ; de Backer, G.* ; Schnell, O.* ; Tuomilehto, J.* ; Wood, D.L.* ; Rydén, L.*

Time-saving screening for diabetes in patients with coronary artery disease: A report from EUROASPIRE IV.

BMJ Open 6:e013835 (2016)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background WHO advocates 2-hour oral glucose tolerance test (OGTT) for detecting diabetes mellitus (DM). OGTT is the most sensitive method to detect DM in patients with coronary artery disease (CAD). Considered time consuming, the use of OGTT is unsatisfactory. A 1-hour plasma glucose (1hPG) test has not been evaluated as an alternative in patients with CAD. Objectives To create an algorithm based on glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and 1hPG limiting the need of a 2-hour plasma glucose (2hPG) in patients with CAD. Methods 951 patients with CAD without DM underwent OGTT. A 2hPG≥11.1mmol/L was the reference for undiagnosed DM. The yield of HbA1c, FPG and 1hPG was compared with that of 2hPG. Results Mean FPG was 6.2±0.9mmol/L, and mean HbA1c 5.8±0.4%. Based on 2hPG≥11.1mmol/L 122 patients (13%) had DM. There was no value for the combination of HbA1c and FPG to rule out or in DM (HbA1c≥6.5%; FPG≥7.0mmol/L). In receiver operating characteristic analysis a 1hPG≥12mmol/L balanced sensitivity and specificity for detecting DM (both=82%; positive and negative predictive values 40% and 97%). A combination of FPG<6.5mmol/L and 1hPG<11mmol/L excluded 99% of DM. A combination of FPG>8.0mmol/L and 1hPG>15mmol/L identified 100% of patients with DM. Conclusions Based on its satisfactory accuracy to detect DM an algorithm is proposed for screening for DM in patients with CAD decreasing the need for a 2-hour OGTT by 71%.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Diabetes ; Fasting Plasma Glucose ; Hba1c ; Oral Glucose Tolerance Test ; Screening
ISSN (print) / ISBN 2044-6055
e-ISSN 2044-6055
Zeitschrift BMJ Open
Quellenangaben Band: 6, Heft: 12, Seiten: , Artikelnummer: e013835 Supplement: ,
Verlag BMJ Publishing Group
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research Type 1 (IDF)