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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Epigenetics and control of RNAs.
Methods Mol. Biol. 1488, 217-237 (2017)
Histone modifications are epigenetic marks that fundamentally impact the regulation of gene expression. Integrating histone modification information in the analysis of gene expression traits (eQTL mapping) has been shown to significantly enhance the prediction of eQTLs. In this chapter, we describe (1) how to perform quantitative trait locus (QTL) analysis using histone modification levels as traits and (2) how to integrate these data with information on RNA expression for the elucidation of the epigenetic control of transcript levels. We will provide a comprehensive introduction into the topic, describe in detail how ChIP-seq data are analyzed and elaborate on how to integrate ChIP-seq and RNA-seq data from a segregating disease animal model for the identification of the epigenetic control of RNA expression.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Chip-seq ; Histone Modifications ; Integrative Analysis ; Qtl Mapping ; Recombinant Inbred Panel ; Rna Expression
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Bandtitel
Systems Genetics
Zeitschrift
Methods in Molecular Biology
Quellenangaben
Band: 1488,
Seiten: 217-237
Verlag
Springer
Verlagsort
Berlin [u.a.]
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Computational Biology (ICB)