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Kragl, M.* ; Schubert, R.* ; Karsjens, H.* ; Otter, S.* ; Bartosinska, B.* ; Jeruschke, K.* ; Weiss, J.* ; Chen, C. ; Alsteens, D.* ; Kuss, O.* ; Speier, S. ; Eberhard, D.* ; Müller, D.J.* ; Lammert, E.*

The biomechanical properties of an epithelial tissue determine the location of its vasculature.

Nat. Commun. 7:13560 (2016)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
An important question is how growing tissues establish a blood vessel network. Here we study vascular network formation in pancreatic islets, endocrine tissues derived from pancreatic epithelium. We find that depletion of integrin-linked kinase (ILK) in the pancreatic epithelial cells of mice results in glucose intolerance due to a loss of the intra-islet vasculature. In turn, blood vessels accumulate at the islet periphery. Neither alterations in endothelial cell proliferation, apoptosis, morphology, Vegfa expression and VEGF-A secretion nor empty sleeves' of vascular basement membrane are found. Instead, biophysical experiments reveal that the biomechanical properties of pancreatic islet cells, such as their actomyosin-mediated cortex tension and adhesive forces to endothelial cells, are significantly changed. These results suggest that a sorting event is driving the segregation of endothelial and epithelial cells and indicate that the epithelial biomechanical properties determine whether the blood vasculature invades or envelops a growing epithelial tissue.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Integrin-linked Kinase; Endothelial Growth-factor; Beta-cell Mass; Cortical Tension; Tumor Angiogenesis; Intercellular-adhesion; Differential Adhesion; Force Spectroscopy; Insulin-secretion; Blood-vessels
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 7, Heft: , Seiten: , Artikelnummer: 13560 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-005
DOI 10.1038/ncomms13560
WOS ID WOS:000390049900001
Scopus ID 85007002610
PubMed ID 27995929
Erfassungsdatum 2016-12-31
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