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Standl, M. ; Tesch, F.* ; Baurecht, H.* ; Rodriguez, E.* ; Müller-Nurasyid, M. ; Gieger, C. ; Peters, A. ; Wang-Sattler, R. ; Prehn, C. ; Adamski, J. ; Kronenberg, F.* ; Schulz, H. ; Koletzko, S.* ; Schikowski, T.* ; von Berg, A.* ; Lehmann, I.* ; Berdel, D.* ; Heinrich, J. ; Schmitt, J.* ; Weidinger, S.*

Association of atopic dermatitis with cardiovascular risk factors and diseases.

J. Invest. Dermatol. 137, 1074-1081 (2017)
Verlagsversion Postprint DOI PMC
Open Access Green
Epidemiological studies suggested an association between atopic dermatitis (AD) and cardiovascular disease (CVD). Therefore, we investigate associations and potential underlying pathways of AD and CVD in large cohort studies: the AOK PLUS cohort (n=1.2Mio), the GINIplus/LISAplus birth cohorts (n=2286), and the KORA F4 cohort (n=2990). Additionally, metabolomics in KORA F4 and established cardiovascular risk loci in genome-wide data on 10,788 AD cases and 30,047 controls were analyzed. Longitudinal analysis of AD patients in AOK PLUS showed slightly increased risk for incident angina pectoris (AP) (adjusted risk ratio 1.17; 95%-confidence interval 1.12-1.23), hypertension (1.04 (1.02-1.06)) and peripheral arterial disease (PAD) (1.15 (1.11-1.19)) but not for myocardial infarction (MI) (1.05 (0.99-1.12) and stroke (1.02 (0.98-1.07)). In KORA F4 and GINIplus/LISAplus, AD was not associated with cardiovascular risk factors (CVRFs) and no differences in metabolite levels were detected. There was no robust evidence for shared genetic risk variants of AD and CVD. This study indicates only a marginally increased risk for AP, hypertension and PAD and no increased risk for MI or stroke in AD patients. Relevant associations of AD with CVRFs reported in US-populations could not be confirmed. Likewise, AD patients did not have increased genetic risk factors for CVD.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Body-mass Index; Myocardial-infarction; Metabolic Syndrome; Ischemic-stroke; Eczema; Adolescents; Children; Obesity; Comorbidity; Prevalence
Sprache
Veröffentlichungsjahr 2017
Prepublished im Jahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 0022-202X
e-ISSN 1523-1747
Zeitschrift Journal of Investigative Dermatology, The
Quellenangaben Band: 137, Heft: 5, Seiten: 1074-1081 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Genetic Epidemiology (IGE)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30201 - Metabolic Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
G-505600-003
G-504100-001
G-504000-001
G-503900-003
G-504091-004
G-504091-003
G-504090-001
DOI 10.1016/j.jid.2016.11.031
WOS ID WOS:000398895200032
Scopus ID 85017527550
PubMed ID 28011146
Erfassungsdatum 2016-12-31
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