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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Cinnamon: Does it hold its promises in cows? Using non-targeted blood serum metabolomics profiling to test the effects of feeding cinnamon to dairy cows undergoing lactation-induced insulin resistance.
Metabolomics 13:28 (2017)
Introduction: Cinnamon exerts insulin-enhancing activity in vitro and was demonstrated to improve blood glucose and lipid profiles in several human studies. Such effects may have an impact on metabolically stressed cows. Objective: To study the effects of cinnamon supplementation during the transition from late pregnancy to early lactation on the metabolism in dairy cows. Methods: Twenty-four Holstein cows (n = 8/group) were assigned to either the control group (CTR; without supplementation) or the supplementation groups [supplemental cinnamon at 20 (LCIN) or 40 (HCIN) g/cow per day (d)] from 28 d before calving until 21 d thereafter. Blood samples were assayed for glucose, nonesterified fatty acids (NEFA), β-hydroxybutyrate (BHBA), and insulin; an index estimating insulin sensitivity (RQUICKI) was calculated. The serum metabolome was characterized in the samples collected from d 14 using a non-targeted approach. Results: The serum concentrations of glucose and insulin did not differ among groups and followed a similar pattern over time. The serum NEFA concentrations were greater in LCIN (d 2, 7, and 14) and HCIN (d 14) than in CTR. On d 14 and 21, LCIN and HCIN had greater serum BHBA concentrations than CTR cows. The top 10 metabolites identified with significantly higher levels in the supplemented than the CTR cows were related to fatty acid metabolism. Conclusion: The data suggest lipolytic and ketogenic effects of cinnamon supplementation in dairy cows during the transition from late gestation to early lactation. The fatty acid metabolites found elevated in the supplemented cows point towards impaired mitochondrial fatty acid β-oxidation.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Cinnamon ; Insulin Resistance ; Metabolite Profile ; Periparturient Cow; Rumen Microbial Fermentation; Essential Oils; Glucose-tolerance; Milk-production; Dose-response; Metabolism; Acid; Cinnamaldehyde; Sensitivity; Performance
ISSN (print) / ISBN
1573-3882
e-ISSN
1573-3890
Zeitschrift
Metabolomics
Quellenangaben
Band: 13,
Heft: 3,
Artikelnummer: 28
Verlag
Springer
Verlagsort
New York, NY
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Experimental Genetics (IEG)
Institute of Experimental Genetics (IEG)