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Clemmensen, C. ; Müller, T.D. ; Woods, S.C.* ; Berthoud, H.R.* ; Seeley, R.J.* ; Tschöp, M.H.

Gut-brain cross-talk in metabolic control.

Cell 168, 758-774 (2017)
Verlagsversion DOI PMC
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Because human energy metabolism evolved to favor adiposity over leanness, the availability of palatable, easily attainable, and calorically dense foods has led to unprecedented levels of obesity and its associated metabolic co-morbidities that appear resistant to traditional lifestyle interventions. However, recent progress identifying the molecular signaling pathways through which the brain and the gastrointestinal system communicate to govern energy homeostasis, combined with emerging insights on the molecular mechanisms underlying successful bariatric surgery, gives reason to be optimistic that novel precision medicines that mimic, enhance, and/or modulate gut-brain signaling can have unprecedented potential for stopping the obesity and type 2 diabetes pandemics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Appetite ; Bariatric Surgery ; Brain ; Diabetes ; Energy Balance ; Gut ; Metabolic Syndrome ; Obesity ; Pharmacology ; Satiety; Gastric Bypass-surgery; Glucagon-like Peptide-1; Vertical Sleeve Gastrectomy; Induced Obese Mice; Melanocortin-4 Receptor Agonist; Intraganglionic Laminar Endings; Randomized Controlled-trial; Resting Energy-expenditure; Diet-induced Obesity; Serum Bile-acids
ISSN (print) / ISBN 0092-8674
e-ISSN 1097-4172
Zeitschrift Cell
Quellenangaben Band: 168, Heft: 5, Seiten: 758-774 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)