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Klimek, L.* ; Schmidt-Weber, C.B. ; Kramer, M.F.* ; Skinner, M.A.* ; Heath, M.D.*

Clinical use of adjuvants in allergen-immunotherapy.

Expert Rev. Clin. Immunol. 13, 599-610 (2017)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Introduction Allergen-specific Immunotherapy (AIT) is the only available treatment aimed to tackle the underlying causes of allergy. The active components of subcutaneous vaccines traditionally consist of natural or modified allergen extracts which can be combined with adjuvant platforms. In recent years new targets have been further developed in an attempt to raise the safety and efficacy profile of AIT. Areas Covered In this review, we discuss the desirable attributes of adjuvants and delivery systems from empiricism to rational design, for current and future clinical applications in AIT. Expert Summary The introduction of novel adjuvants, in combination with active targets, has been demonstrated to reduce side-effects of AIT, increase clinical efficacy of allergy treatment and reduce the number of doses. The evolution of vaccine development for AIT is entering a phase of scientific progress that challenges dogmas. Over the past century the traditional concept of immunotherapy, entailing long-course administration of native extract preparations and first generation adjuvants has seen evolution in the past decade from proof-of-concept to clinical development pipelines encompassing the advent of second generation adjuvants and delivery systems that form essential components of modern AIT development.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Allergic Rhinitis ; Cpg-motifs ; Monophosphoryl Lipid A ; Adjuvant ; Microcrystalline Tyrosine ; Nanoparticles ; Subcutaneous ; Vaccine; Monophosphoryl-lipid-a; Virus-like Particles; Peanut Oral Immunotherapy; Aluminum Adjuvants; Immune-responses; Apoptotic Cells; Dendritic Cells; Vaccine Development; Nalp3 Inflammasome; Structural Basis
ISSN (print) / ISBN 1744-666X
Zeitschrift Expert Review of Clinical Immunology
Quellenangaben Band: 13, Heft: 6, Seiten: 599-610 Artikelnummer: , Supplement: ,
Verlag Expert Reviews
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)