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Warren, H.R.* ; Evangelou, E.* ; Cabrera, C.P.* ; Gao, H.* ; Ren, M.* ; Mifsud, B.* ; Ntalla, I.* ; Surendran, P.* ; Liu, C.* ; Cook, J.P.* ; Kraja, A.T.* ; Drenos, F.* ; Loh, M.* ; Verweij, N.* ; Marten, J.* ; Karaman, I.* ; Lepe, M.P.* ; O'Reilly, P.F.* ; Knight, J.* ; Snieder, H.* ; Kato, N.* ; He, J.* ; Tai, E.S.* ; Said, M.A.* ; Porteous, D.J.* ; Alver, M.* ; Poulter, N.* ; Farrall, M.* ; Gansevoort, R.T.* ; Padmanabhan, S.* ; Mägi, R.* ; Stanton, A.* ; Connell, J.* ; Bakker, S.J.* ; Metspalu, A.* ; Shields, D.C.* ; Thom, S.* ; Brown, M.* ; Sever, P.* ; Esko, T.* ; Hayward, C.* ; van der Harst, P.* ; Saleheen, D.* ; Chowdhury, R.* ; Chambers, J.C.* ; Chasman, D.I.* ; Chakravarti, A.* ; Newton-Cheh, C.* ; Lindgren, C.M.* ; Levy, D.* ; Kooner, J.S.* ; Keavney, B.* ; Tomaszewski, M.* ; Samani, N.J.* ; Howson, J.M.M.* ; Tobin, M.D.* ; Munroe, P.B.* ; Ehret, G.B.* ; Wain, L.V.* ; ICBP Consortium (Ried, J.S. ; Gieger, C. ; Peters, A.)

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Nat. Genet. 49, 403-415 (2017)
Postprint DOI PMC
Open Access Green
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Coronary-artery-disease; Endothelial-cell; Myocardial-infarction; Neurotrophic Factor; Nadph Oxidase; Uk Biobank; Key Role; In-vivo; Hypertension; Common
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 49, Heft: 3, Seiten: 403-415 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)