PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Dai, B.* ; Grau, M.* ; Juilland, M.* ; Klener, P.* ; Höring, E.* ; Molinsky, J.* ; Schimmack, G. ; Aukema, S.M.* ; Hoster, E.* ; Vogt, N.* ; Staiger, A.M.* ; Erdmann, T.* ; Xu, W.* ; Erdmann, K.* ; Dzyuba, N.* ; Madle, H.* ; Berdel, W.E.* ; Trneny, M.* ; Dreyling, M.* ; Jöhrens, K.* ; Lenz, P.* ; Rosenwald, A.* ; Siebert, R.* ; Tzankov, A.* ; Klapper, W.* ; Anagnostopoulos, I.* ; Krappmann, D. ; Ott, G.* ; Thome, M.* ; Lenz, G.*

B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.

Blood 129, 333-346 (2017)
Verlagsversion DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mantle cell lymphoma (MCL) is a mature B-cell lymphoma characterized by poor clinical outcome. Recent studies revealed the importance of B-cell receptor (BCR) signaling in maintaining MCL survival. However, it remains unclear which role MALT1, an essential component of the CARD11-BCL10-MALT1 complex that links BCR signaling to the NF-κB pathway, plays in the biology of MCL. Here we show that a subset of MCLs is addicted to MALT1, as its inhibition by either RNA or pharmacologic interference induced cytotoxicity both in vitro and in vivo. Gene expression profiling following MALT1 inhibition demonstrated that MALT1 controls an MYC-driven gene expression network predominantly through increasing MYC protein stability. Thus, our analyses identify a previously unappreciated regulatory mechanism of MYC expression. Investigating primary mouse splenocytes, we could demonstrate that MALT1-induced MYC regulation is not restricted to MCL, but represents a common mechanism. MYC itself is pivotal for MCL survival because its downregulation and pharmacologic inhibition induced cytotoxicity in all MCL models. Collectively, these results provide a strong mechanistic rationale to investigate the therapeutic efficacy of targeting the MALT1-MYC axis in MCL patients.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
13.164
2.502
36
36
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Nf-kappa-b; Paracaspase Malt1; T-cells; Activation; Cleavage; Lubac; Pathogenesis; Survival; Proliferation; Inactivation
Sprache
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Zeitschrift Blood
Quellenangaben Band: 129, Heft: 3, Seiten: 333-346 Artikelnummer: , Supplement: ,
Verlag American Society of Hematology
Verlagsort Washington
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Signaling and Translation (SAT)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-509800-002
DOI 10.1182/blood-2016-05-718775
WOS ID WOS:000396529800011
PubMed ID 27864294
Erfassungsdatum 2017-03-17
[➜Korrektur melden]