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Lorenz, L.* ; Peter, A. ; Arand, J.* ; Springer, F.* ; Poets, C.F.* ; Franz, A.R.*

Reference ranges of reticulocyte haemoglobin content in preterm and term infants: A retrospective analysis.

Neonatology 111, 189-194 (2017)
Verlagsversion DOI PMC
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: Despite iron supplementation, some preterm infants develop iron deficiency (ID). The optimal iron status parameter for early detection of ID has yet to be determined. Objective: To establish reference ranges for reticulocyte haemoglobin content (Ret-He) in preterm and term infants and to identify confounding factors. Methods: Retrospective analyses of Ret-He and complete blood count in infants with a clinically indicated blood sample obtained within 24 h after birth. Results: Mean (SD) Ret-He was 30.7 (3.0) pg in very preterm infants with a gestational age (GA) of < 30 weeks (n = 55), 31.2 (2.6) pg in moderately preterm infants (GA 3036 weeks, n = 241) and 32.0 (3.2) pg in term infants (GA = 37 weeks, n = 216). The 2.5th percentile of Ret-He across all GA groups was 25 pg, with a weak correlation between Ret-He and GA (r = 0.18). Moreover, only weak/no correlations were found between Ret-He and C-reactive protein (r = 0.18), interleukin 6 (IL-6) (r = 0.03) and umbilical artery pH (r = -0.07).There was a slight variation in Ret-He with mode of delivery [normal vaginal delivery: 32.3 (3.2) pg, secondary caesarean section (CS): 31.4 (3.0) pg, instrumental delivery: 31.3 (2.7) pg and elective CS: 31.2 (2.8) pg]. Conclusion: GA at birth has a negligible impact on Ret-He, and the lower limit of the normal reference range in newborns within 24 h after birth can be set to 25 pg. Moreover, Ret-He seems to be a robust parameter which is not influenced by perinatal factors within the first 24 h after birth.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Iron Deficiency ; Premature Infant ; Reticulocyte Haemoglobin Content ; Gestational Age-specific Reference Ranges; Enteral Iron Supplementation; Than 1301 Grams; Red-blood-cell; Randomized-trial; Birth-weight; Cord Blood; Clinical Utility; Parameters; Age; Deficiency
ISSN (print) / ISBN 1661-7800
e-ISSN 1661-7819
Zeitschrift Neonatology
Quellenangaben Band: 111, Heft: 3, Seiten: 189-194 Artikelnummer: , Supplement: ,
Verlag Karger
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)