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Xia, Y.* ; Protzer, U.

Control of hepatitis B virus by cytokines.

Viruses 9:18 (2017)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Hepatitis B virus (HBV) infection remains a major public health problem worldwide with more than 240 million individuals chronically infected. Current treatments can control HBV replication to a large extent, but cannot eliminate HBV infection. Cytokines have been shown to control HBV replication and contribute to HBV cure in different models. Cytokines play an important role in limiting acute HBV infection in patients and mediate a non-cytolytic clearance of the virus. In this review, we summarize the effects of cytokines and cytokine-induced cellular signaling pathways on different steps of the HBV life cycle, and discuss possible strategies that may contribute to the eradication of HBV through innate immune activation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Hepatitis B Virus (hbv) ; Cytokine ; Interferon ; Interferon-induced Gene (isg) ; Cccdna ; Therapy; Chronic Hcv Infection; Plasma Half-life; T-cells; Viral-rna; Polyethylene-glycol; Protein-synthesis; Gene-expression; Transgenic Mice; Core Promoter; Mouse Model
Sprache
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1999-4915
e-ISSN 1999-4915
Zeitschrift Viruses
Quellenangaben Band: 9, Heft: 1, Seiten: , Artikelnummer: 18 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-502700-003
PubMed ID PMC5294987
DOI 10.3390/v9010018
WOS ID WOS:000396476200017
Scopus ID 85010830980
Erfassungsdatum 2017-06-01
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