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Kolb, H.J.

Hematopoietic stem cell transplantation and cellular therapy.

HLA 89, 267-277 (2017)
DOI PMC
Allogeneic stem cell transplantation is a form of immunotherapy that has increased the chances of survival for patients with relapsed leukemia and high risk leukemia in remission. The major obstacles are graft-vs-host disease (GVHD) involving vital organs and infections. A most efficacious prophylaxis of GVHD is by depleting of T cells from the graft. However, problems of T-depleted transplants are rejection, slow recovery of the immune system and high incidence of relapse of leukemia and myeloma. The major problem of allogeneic transplantation is the separation of a graft-vs-leukemia (GVL) effect from GVHD. This review will summarize the factors influencing GVHD, ways to exploit rapid advances in our knowledge of histocompatibility, chimerism and tolerance for fostering GVL over GVHD, and in particular the use of cellular therapies including donor lymphocyte infusions for disease control.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Allogeneic Hematologic Stem Cell Transplantation ; Leukemia ; Post-transplant Relapse; Versus-host-disease; Bone-marrow-transplantation; Donor Lymphocyte Infusion; Acute Myeloid-leukemia; Minor-histocompatibility-antigens; Chronic Myelogenous Leukemia; Necrosis-factor-alpha; Acute Graft; T-cells; Multiple-myeloma
ISSN (print) / ISBN 2059-2302
e-ISSN 2059-2310
Zeitschrift HLA : immune response genetics
Quellenangaben Band: 89, Heft: 5, Seiten: 267-277 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Oxford, UK
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CCG Immunotherapy (KKG-KIT)