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Kosinska, A. ; Bauer, T. ; Protzer, U.

Therapeutic vaccination for chronic hepatitis B.

Curr. Opin. Virol. 23, 75-81 (2017)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A therapeutic vaccine is meant to activate the patient's immune system to fight and finally control or ideally eliminate an already established infectious pathogen. Whereas the success of prophylactic vaccination is based on rapid antibody-mediated neutralization of an invading pathogen, control and elimination of persistent viruses such as hepatitis, herpes or papilloma viruses requires multi-specific and polyfunctional effector T cell responses. These are ideally directed against continuously expressed viral antigens to keep the pathogen in check. Activation of a humoral immune response in order to lower viral antigen load and to limit virus spread, however, confers an additional benefit. Therapeutic vaccines are under development for a number of chronic infections and require an intelligent vaccine design. Hepatitis B virus (HBV) infection may serve as a prime example since a spontaneous, immune-mediated recovery of chronic hepatitis B and an elimination of the virus is possible even if it is observed only in very rare cases. In this review, we summarize the current knowledge and potential improvements of therapeutic vaccines for chronic hepatitis B.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Vaccinia Virus Ankara; Hbv-transgenic Mice; T-cell Responses; Boost Vaccination; Viral-hepatitis; Hepatocellular-carcinoma; Nonviral Delivery; Suppressor-cells; Immune-responses; Surface-antigen
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1879-6257
e-ISSN 1879-6265
Zeitschrift Current Opinion in Virology
Quellenangaben Band: 23, Heft: , Seiten: 75-81 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
POF Topic(s) 30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-502700-003
G-502700-002
G-508600-010
PubMed ID 28453967
DOI 10.1016/j.coviro.2017.03.011
WOS ID WOS:000404702000013
Scopus ID 85018633147
Erfassungsdatum 2017-05-02
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