Hinweise zu Qualitätskriterien von Zeitschriften
Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016
CC Licencences
Metriken für Publikationen
Startseite
Login
English
Neuer EVA Antrag
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
HGF Fortschrittsbericht
OA Publikationen
Neue Publikation eintragen
Neue Publikation holen aus...
Fehlende Publikation melden
Ansprechpartner
Hilfe
Bibliometrische Indikatoren
Text
Endnote (RIS)
BibTeX
DOI
 |
|
möglich sobald bei der ZB eingereicht worden ist.
Glutathione peroxidase 4 and ferroptosis.
In: Selenium: Its Molecular Biology and Role in Human Health. 2016. 511-521 ( ; 4)
Glutathione peroxidase 4 (Gpx4) is one of eight members of the mammalian glutathione peroxidase family of enzymes. Gpx4 is unique due to its capacity to efficiently reduce phospholipid hydroperoxides. Additionally, it has been recognized that Gpx4 governs a novel form of non-apoptotic cell death, named ferroptosis. Ferroptosis was initially described to be induced by small molecules in specific tumor types and in engineered cells overexpressing oncogenic RAS. Recently, its relevance in non-transformed cells and tissues was highlighted expanding the importance of this cell death pathway in several pathophysiological contexts, encompassing immunity, neurodegenerative diseases and tissue damage upon ischemia/reperfusion scenarios. Importantly, regulation of selenoprotein biosynthesis emerges as an important factor in control of ferroptosis. In this chapter, we present an updated view on the ferroptotic process as well as review the implications of how selenoprotein expression might impact on ferroptosis per se.
Scopus
Cited By
Cited By
Altmetric
3
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Sammelbandbeitrag/Buchkapitel
Schlagwörter
Ferroptotic Signaling ; Ischemia/reperfusion Injury ; Lipid Peroxidation ; Liproxstatin-1 ; Mevalonate Pathway ; Neurodegeneration ; Non-apoptotic Cell Death ; Phgpx ; Phospholipid Hydroperoxide Glutathione Peroxidase ; Regulated Necrosis
Sprache
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
2017
ISSN (print) / ISBN
978-3-319-41281-8
e-ISSN
978-3-319-41283-2
Bandtitel
Selenium: Its Molecular Biology and Role in Human Health
Quellenangaben
Band: 4,
Seiten: 511-521
Institut(e)
Institute of Developmental Genetics (IDG)
POF Topic(s)
30204 - Cell Programming and Repair
30204 - Cell Programming and Repair
Forschungsfeld(er)
Genetics and Epidemiology
Genetics and Epidemiology
PSP-Element(e)
G-508500-007
G-500500-001
G-500500-001
Scopus ID
85018554656
Erfassungsdatum
2017-06-06