OBJECTIVE: Surgical treatment of spinal tumors regularly includes spinal instrumentation with pedicle screws. Most modern pedicle screws are made of titanium alloy, which is associated with artifacts on postoperative imaging such as CT and/or MRI. These artifacts hamper radiation treatment planning and execution and follow-up imaging. Recently, carbon fiber reinforced polyetheretherketone (CFRP) implants became available for posterior instrumentation with the aim to reduce imaging artifacts by implants. METHODS: Patients harboring spinal tumors underwent posterior stabilization using carbon-fiber reinforced polyetheretherketone (CFRP) pedicle screws. Postoperative imaging was evaluated for implant artifacts. Radiation planning was assessed. RESULTS: Thirtyfive patients with spinal tumors were assessed (metastases n=30, lymphoma n=2, myeloma n=1, chordoma n=1, fibrous dysplasia n=1). Implantation of CFRP implants was feasible in all but one case. Postoperative images show reduced artifacts in comparison to standard titanium alloy implants. Implant position and integrity is sufficiently assessable despite reduced image contrast. Radiation planning is improved. CONCLUSIONS: Carbon fiber reinforced PEEK pedicle screws reduce image artifacts on CT and MRI. Thereby, they are a valuable and feasible option for spinal instrumentations in patients harboring spinal tumors where postoperative imaging and radiation therapy planning are necessary and might be crucial for long-term outcome and overall survival.