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Melin, B.S.* ; Barnholtz-Sloan, J.S.* ; Wrensch, M.R.* ; Johansen, C.T.* ; Il'yasova, D.* ; Kinnersley, B.* ; Ostrom, Q.T.* ; Labreche, K.* ; Chen, Y.* ; Armstrong, G.* ; Liu, Y.* ; Eckel-Passow, J.E.* ; Decker, P.A.* ; Labussière, M.* ; Idbaih, A.* ; Hoang-Xuan, K.* ; di Stefano, A.L.* ; Mokhtari, K.* ; Delattre, J.Y.* ; Broderick, P.* ; Galan, P.* ; Gousias, K.* ; Schramm, J.* ; Schoemaker, M.J.* ; Fleming, S.J.* ; Herms, S.* ; Heilmann, S.* ; Noethen, M.M.* ; Wichmann, H.-E. ; Schreiber, S.* ; Swerdlow, A.* ; Lathrop, M* ; Simon, M.* ; Sanson, M.* ; Andersson, U.* ; Rajaraman, P.* ; Chanock, S.* ; Linet, M.* ; Wang, Z.* ; Yeager, M.* ; Wiencke, J.K.* ; Hansen, H.* ; McCoy, L.S.* ; Rice, T.* ; Kosel, M.L.* ; Sicotte, H.* ; Amos, C.I.* ; Bernstein, J.L.* ; Davis, F.G.* ; Lachance, D.H.* ; Lau, C.* ; Merrell, R.T.* ; Shildkraut, J.* ; Ali-Osman, F.* ; Sadetzki, S.* ; Scheurer, M.* ; Shete, S.* ; Lai, R.K.* ; Claus, E.B.* ; Olson, S.H.* ; Jenkins, R.B.* ; Houlston, R.S.* ; Bondy, M.L.*

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.

Nat. Genet. 49, 789-794 (2017)
Postprint DOI PMC
Open Access Green
Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 x 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 x 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 x 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 x 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 x 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 x 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 x 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 x 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 x 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 x 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 x 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 x 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 x 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Central-nervous-system; Telomere Length; Breast-cancer; Adult Glioma; Risk; Complex; Population; Variants; Disease; Loci
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 49, Heft: 5, Seiten: 789-794 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Epidemiology II (EPI2)