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Kullmann, S.
;
Heni, M.
;
Veit, R.
; Scheffler, K.* ;
Machann, J.
;
Häring, H.-U.
; Fritsche, A.* ;
Preissl, H.
Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger.
Sci. Rep.
7
:1627 (2017)
Verlagsversion
Forschungsdaten
DOI
Open Access Gold
möglich sobald bei der ZB eingereicht worden ist.
Abstract
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Zusatzinfos
© 2017 The Author(s).Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction. Intranasal insulin is a promising tool to investigate central insulin action in humans. We evaluated the acute effects of 160 U intranasal insulin on resting-state brain functional connectivity in healthy young adults. Twenty-five lean and twenty-two overweight and obese participants underwent functional magnetic resonance imaging, on two separate days, before and after intranasal insulin or placebo application. Insulin compared to placebo administration resulted in increased functional connectivity between the prefrontal regions of the default-mode network and the hippocampus as well as the hypothalamus. The change in hippocampal functional connectivity significantly correlated with visceral adipose tissue and the change in subjective feeling of hunger after intranasal insulin. Mediation analysis revealed that the intranasal insulin induced hippocampal functional connectivity increase served as a mediator, suppressing the relationship between visceral adipose tissue and hunger. The insulin-induced hypothalamic functional connectivity change showed a significant interaction with peripheral insulin sensitivity. Only participants with high peripheral insulin sensitivity showed a boost in hypothalamic functional connectivity. Hence, brain insulin action may regulate eating behavior and facilitate weight loss by modifying brain functional connectivity within and between cognitive and homeostatic brain regions.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Korrespondenzautor
Schlagwörter
Mild Cognitive Impairment; Food-intake; Intraventricular Insulin; Improves Cognition; Apoe Genotype; Older-adults; Body-weight; Early Ad; Sensitivity; Resistance
Keywords plus
ISSN (print) / ISBN
2045-2322
e-ISSN
2045-2322
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Zeitschrift
Scientific Reports
Quellenangaben
Band: 7,
Heft: 1,
Seiten: ,
Artikelnummer: 1627
Supplement: ,
Reihe
Verlag
Nature Publishing Group
Verlagsort
London
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Veröffentlichungsnummer
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen