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Non-invasive volumetric optoacoustic imaging of cardiac cycles in acute myocardial infarction model in real-time.
Proc. SPIE 10064:100641D (2017)
Extraction of murine cardiac functional parameters on a beat-by-beat basis remains challenging with the existing imaging modalities. Novel methods enabling in vivo characterization of functional parameters at a high temporal resolution are poised to advance cardiovascular research and provide a better understanding of the mechanisms underlying cardiac diseases. We present a new approach based on analyzing contrast-enhanced optoacoustic (OA) images acquired at high volumetric frame rate without using cardiac gating or other approaches for motion correction. Acute myocardial infarction was surgically induced in murine models, and the method was modified to optimize for acquisition of artifact-free optoacoustic data. Infarcted hearts could be differentiated from healthy controls based on a significantly higher pulmonary transit time (PTT: infarct 2.07 s vs. healthy 1.34 s), while no statistically significant difference was observed in the heart rate (318 bpm vs. 309 bpm). In combination with the proven ability of optoacoustics to track targeted probes within the injured myocardium, our method is capable of depicting cardiac anatomy, function, and molecular signatures on a beat-by-beat basis, both with high spatial and temporal resolution, thus providing new insights into the study of myocardial ischemia.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Acute Myocardial Infarction ; Heart Rate ; Optoacoustic Imaging ; Pulmonary Transit Time ; Real-time Imaging
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Konferenztitel
Photons Plus Ultrasound: Imaging and Sensing 2017
Konferzenzdatum
29 January - 1 February 2017
Konferenzort
San Francisco, California, United States
Zeitschrift
Proceedings of SPIE
Quellenangaben
Band: 10064,
Artikelnummer: 100641D
Verlag
SPIE
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed