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Altmann, M. ; Pich, D. ; Ruiss, R. ; Wang, J.* ; Sugden, B.* ; Hammerschmidt, W.

Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes.

Proc. Natl. Acad. Sci. U.S.A. 103, 14188-14193 (2006)
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EBV is a paradigm for human tumor viruses because, although it infects most people benignly, it also can cause a variety of cancers. Both in vivo and in vitro, EBV infects B lymphocytes in G0, induces them to become blasts, and can maintain their proliferation in cell culture or in vivo as tumors. How EBV succeeds in these contrasting cellular environments in expressing its genes that control the host has not been explained. We have genetically dissected the EBV nuclear antigen 1 (EBNA1) gene that is required for replication of the viral genome, to elucidate its possible role in the transcription of viral genes. Strikingly, EBNA1 is essential to drive transcription of EBV's transforming genes after infection of primary B lymphocytes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter transcription; regulation; high-mobility group A protein; HMGA1a; EPSTEIN-BARR-VIRUS; LYMPHOBLASTOID CELL-LINES; LATENT MEMBRANE-PROTEIN-1; DNA-REPLICATION; INITIAL-STAGES; C-PROMOTER; B-CELLS; INFECTION; EBNA-1; ORIP
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Zeitschrift Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Band: 103, Heft: 38, Seiten: 14188-14193 Artikelnummer: , Supplement: ,
Verlag National Academy of Sciences
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Gene Vector (AGV)