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Vegiopoulos, A.* ; Rohm, M.* ; Herzig, S.

Adipose tissue: Between the extremes.

EMBO J. 36, 1999-2017 (2017)
Verlagsversion DOI PMC
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Adipose tissue represents a critical component in healthy energy homeostasis. It fulfills important roles in whole-body lipid handling, serves as the body's major energy storage compartment and insulation barrier, and secretes numerous endocrine mediators such as adipokines or lipokines. As a consequence, dysfunction of these processes in adipose tissue compartments is tightly linked to severe metabolic disorders, including obesity, metabolic syndrome, lipodystrophy, and cachexia. While numerous studies have addressed causes and consequences of obesity-related adipose tissue hypertrophy and hyperplasia for health, critical pathways and mechanisms in (involuntary) adipose tissue loss as well as its systemic metabolic consequences are far less understood. In this review, we discuss the current understanding of conditions of adipose tissue wasting and review microenvironmental determinants of adipocyte (dys)function in related pathophysiologies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Adipose Tissue Dysfunction ; Cachexia ; Lipodystrophy ; Metabolic Disorders ; Obesity; Activated Protein-kinase; Congenital Generalized Lipodystrophy; Induced Insulin-resistance; Familial Partial Lipodystrophy; Leptin-replacement Therapy; Cancer-associated Cachexia; Tumor-bearing Rats; High-fat-diet; Extracellular-matrix; Metabolic Dysfunction
ISSN (print) / ISBN 0261-4189
e-ISSN 1460-2075
Zeitschrift EMBO Journal, The
Quellenangaben Band: 36, Heft: 14, Seiten: 1999-2017 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Heidelberg, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)