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Ovsepian, S.V.

The birth of the synapse.

Brain Struct. Funct. 222, 3369–3374 (2017)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
It has long been held that the rise of neurons as a specialized cell type also marked the onset of the grand evolutionary journey for chemical synapses. Research over recent decades has shown, however, that the most dynamic chapters of synaptic history have been ‘written’ out of the context of neurobiology and neuronal evolution, dating back to the early metazoa and unicellular living forms. Here, I consider and discuss emerging evidence suggesting the exaptive origin of chemical synapses, via tinkering and neo-functionalization of already existent junctional morphologies and constituents of primeval paracrine signalling. Through combination and collateral use of long-established structures and functions, a remarkable enrichment of regulatory and control mechanisms of complex living organisms was achieved, without large-scale reorganization of the genome, with tremendous impact on the evolution and life on our planet.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Chemical Synapse ; Exaptation ; Gap Junctions ; Synaptic Evolution; Electrical Synapses; Developing Neocortex; Neuronal Networks; Evolution; Diversity; System
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1863-2653
e-ISSN 1863-2661
Zeitschrift Brain Structure & Function
Quellenangaben Band: 222, Heft: 8, Seiten: 3369–3374 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
PubMed ID 28612096
DOI 10.1007/s00429-017-1459-2
WOS ID WOS:000414761700001
Scopus ID 85020724290
Erfassungsdatum 2017-07-26
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