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Karlas, A. ; Reber, J. ; Diot, G.* ; Bozhko, D. ; Anastasopoulou, M. ; Ibrahim, T.* ; Schwaiger, M.* ; Hyafil, F.* ; Ntziachristos, V.

Flow-mediated dilatation test using optoacoustic imaging: A proof-of-concept.

Biomed. Opt. Express 8, 3395-3403 (2017)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Label-free multispectral optoacoustic tomography (MSOT) has recently shown superior performance in visualizing the morphology of human vasculature, especially of smaller vessels, compared to ultrasonography. Herein, we extend these observations towards MSOT interrogation of macrovascular endothelial function. We employed a real-time handheld MSOT scanner to assess flow-mediated dilatation (FMD), a technique used to characterize endothelial function. A data processing scheme was developed to quantify the dimensions and diameter changes of arteries in humans and determine wall distensibility parameters. By enabling high-resolution delineation of the blood-vessel wall in a cross-sectional fashion, the findings suggest MSOT as a capable alternative to ultrasonography for clinical FMD measurements.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter (000.1430) Biology And Medicine ; (110.5120) Photoacoustic Imaging ; (110.5125) Photoacoustics ; (170.3880) Medical And Biological Imaging ; (170.5380) Physiology; Brachial-artery; Vasodilation; Risk
ISSN (print) / ISBN 2156-7085
e-ISSN 2156-7085
Zeitschrift Biomedical Optics Express
Quellenangaben Band: 8, Heft: 7, Seiten: 3395-3403 Artikelnummer: , Supplement: ,
Verlag Optical Society of America (OSA)
Verlagsort Washington
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)