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Zscheppang, K.* ; Berg, J.V.* ; Hedtrich, S.* ; Verheyen, L.* ; Wagner, D.E. ; Suttorp, N.* ; Hippenstiel, S.* ; Hocke, A.C.*

Human pulmonary 3D models for translational research.

Biotechnol. J. 13:1700341 (2018)
Postprint DOI PMC
Open Access Green
Lung diseases belong to the major causes of death worldwide. Recent innovative methodological developments now allow more and more for the use of primary human tissue and cells to model such diseases. In this regard, the review covers bronchial air-liquid interface cultures, precision cut lung slices as well as ex vivo cultures of explanted peripheral lung tissue and de-/re-cellularization models. Diseases such as asthma or infections are discussed and an outlook on further areas for development is given. Overall, the progress in ex vivo modeling by using primary human material could make translational research activities more efficient by simultaneously fostering the mechanistic understanding of human lung diseases while reducing animal usage in biomedical research.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter 3d Models ; Alveolar ; Bronchial ; Human Lung Tissue ; Infections; Human Lung-tissue; Slow-reacting Substance; Airway Epithelial-cells; Nontypable Haemophilus-influenzae; Pluripotent Stem-cells; Human Isolated Bronchi; In-vitro Models; Organs-on-chips; Cigarette-smoke; Animal-models
ISSN (print) / ISBN 1860-6768
Zeitschrift Biotechnology Journal
Quellenangaben Band: 13, Heft: 1, Seiten: , Artikelnummer: 1700341 Supplement: ,
Verlag Wiley
Verlagsort Weinheim
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Lung Repair and Regeneration (LRR)