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Kamel, M.* ; Ninov, N.

Catching new targets in metabolic disease with a zebrafish.

Curr. Opin. Pharmacol. 37, 41-50 (2017)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Traditionally, the development of novel therapeutics for metabolic diseases has relied mainly on high-throughput screening using biochemical or cell-based assays. While this approach represents a driving force in drug discovery, there is also a need to perform large-scale screens without disrupting inter-organ communication and tissue architecture, essential components for understanding the complexity of metabolic regulation and the identification of small molecules with appropriate biological activities in vivo. Hence, the zebrafish Danio rerio is gaining popularity in metabolic research and drug discovery, as this animal model allows screening of small molecules in the context of the whole-organism. Moreover, the zebrafish exhibits conserved function of the pancreas, liver and adipose tissue, which can be leveraged to identify novel targets in metabolic regulation, as well as to study the role of conserved genes associated with the risk of metabolic diseases in humans. Here we highlight recent advances in the identification of targets in metabolic regulation using the zebrafish as a model.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Beta-cell Mass; Body-fat Distribution; Genetic Screen; Adipose-tissue; Liver-disease; Glucose-homeostasis; Danio-rerio; In-vivo; Regeneration; Pancreas
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1471-4892
e-ISSN 1471-4973
Zeitschrift Current opinion in pharmacology
Quellenangaben Band: 37, Heft: , Seiten: 41-50 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-010
DOI 10.1016/j.coph.2017.08.007
WOS ID WOS:000419423700009
Scopus ID 85028707862
PubMed ID 28888214
Erfassungsdatum 2017-09-20
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