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Oyaga Landa, F.J. ; Dean-Ben, X.L. ; Montero de Espinosa, F.* ; Razansky, D.

Real-time three-dimensional temperature mapping in photothermal therapy with optoacoustic tomography.

Proc. SPIE 10415:104150A (2017)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Ablation and photothermal therapy are widely employed medical protocols where the selective destruction of tissue is a necessity as in cancerous tissue removal or vascular and brain abnormalities. Tissue denaturation takes place when the temperature reaches a threshold value while the time of exposure determines the lesion size. Therefore, the spatio-temporal distribution of temperature plays a crucial role in the outcome of these clinical interventions. We demonstrate fast volumetric temperature mapping with optoacoustic tomography based on real-time optoacoustic readings from the treated region. The performance of the method was investigated in tissue-mimicking phantom experiments. The new ability to non-invasively measure temperature volumetrically in an entire treated region with high spatial and temporal resolutions holds potential for improving safety and efficacy of thermal ablation and to advance the general applicability of laser-based therapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Ablation Of Tissue ; Optoacoustic Imaging ; Optoacoustic Tomography ; Temperature
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Konferenztitel European Conferences on Biomedical Optics 2017
Konferzenzdatum 25-29 June 2017
Konferenzort Munich, Germany
Zeitschrift Proceedings of SPIE
Quellenangaben Band: 10415, Heft: , Seiten: , Artikelnummer: 104150A Supplement: ,
Verlag SPIE
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)