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Fischer, I.P. ; Irmler, M. ; Meyer, C.W.E.* ; Sachs, S. ; Neff, F. ; Hrabě de Angelis, M. ; Beckers, J. ; Tschöp, M.H. ; Hofmann, S.M. ; Ussar, S.

A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue.

Int. J. Obes. 42, 507-517 (2018)
Verlagsversion Postprint DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Background/Objectives:Dieting is a popular yet often ineffective way to lower body weight, as the majority of people regain most of their pre-dieting weights in a relatively short time. The underlying molecular mechanisms driving weight regain and the increased risk for metabolic disease are still incompletely understood. Here we investigate the molecular alterations inherited from a history of obesity.Methods:In our model, male high-fat diet (HFD)-fed obese C57BL/6J mice were switched to a low caloric chow diet, resulting in a decline of body weight to that of lean mice. We measured body composition, as well as metrics of glucose, insulin and lipid homeostasis. This was accompanied by histological and gene expression analysis of adipose tissue and liver to assess adipose tissue inflammation and hepatosteatosis. Moreover, acute hypothalamic response to (re-) exposure to HFD was assessed by qPCR.Results & Conclusions:Within 7 weeks after diet switch, most obesity-associated phenotypes, such as body mass, glucose intolerance and blood metabolite levels were reversed. However, hepatic inflammation, hepatic steatosis as well as hypertrophy and inflammation of perigonadal, but not subcutaneous, adipocytes persisted in formerly obese mice. Transcriptional profiling of liver and perigonadal fat revealed an upregulation of pathways associated with immune function and cellularity. Thus, we show that weight reduction leaves signs of inflammation in liver and perigonadal fat, indicating that persisting proinflammatory signals in liver and adipose tissue could contribute to an increased risk of formerly obese subjects to develop the metabolic syndrome upon recurring weight gain.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Diet-induced Obesity; Weight-loss; Bariatric Surgery; Insulin-resistance; Follow-up; Humans; Fat; Mice; Restriction; Disease
Sprache
Veröffentlichungsjahr 2018
Prepublished im Jahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 0307-0565
e-ISSN 1476-5497
Zeitschrift International Journal of Obesity
Quellenangaben Band: 42, Heft: 3, Seiten: 507-517 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
Institute of Experimental Genetics (IEG)
Institute of Diabetes and Regeneration Research (IDR)
POF Topic(s) 30201 - Metabolic Health
30502 - Diabetes: Pathophysiology, Prevention and Therapy
Forschungsfeld(er) Helmholtz Diabetes Center
Genetics and Epidemiology
PSP-Element(e) G-502200-001
G-508600-009
G-553400-001
G-500600-004
G-502390-001
G-500600-001
G-500600-006
DOI 10.1038/ijo.2017.224
WOS ID WOS:000428844600030
Scopus ID 85044588822
PubMed ID 28901330
Erfassungsdatum 2017-09-25
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