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Entenmann, L.* ; Pietzner, M.* ; Artati, A. ; Hannemann, A.* ; Henning, A.K.* ; Kastenmüller, G. ; Völzke, H.* ; Nauck, M.* ; Adamski, J. ; Wallaschofski, H.* ; Friedrich, N.*

Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample.

PLoS ONE 12:e0184721 (2017)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Recent research suggested a metabolic implication of osteocalcin (OCN) in e.g. insulin sensitivity or steroid production. We used an untargeted metabolomics approach by analyzing plasma and urine samples of 931 participants using mass spectrometry to reveal further metabolic actions of OCN. Several detected relations between OCN and metabolites were strongly linked to renal function, however, a number of associations remained significant after adjustment for renal function. Intermediates of proline catabolism were associated with OCN reflecting the implication in bone metabolism. The association to kynurenine points towards a pro-inflammatory state with increasing OCN. Inverse relations with intermediates of branch-chained amino acid metabolism suggest a link to energy metabolism. Finally, urinary surrogate markers of smoking highlight its adverse effect on OCN metabolism. In conclusion, the present study provides a read-out of metabolic actions of OCN. However, most of the associations were weak arguing for a limited role of OCN in whole-body metabolism.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Nitric-oxide Synthase; Osteoblast-like Cells; Bone-mineral Density; General-population; Functional-role; Insulin; Expression; Fracture; Receptor; Mass
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 12, Heft: 9, Seiten: , Artikelnummer: e0184721 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)
Molekulare Endokrinologie und Metabolismus (MEM)
POF Topic(s) 30505 - New Technologies for Biomedical Discoveries
30201 - Metabolic Health
Forschungsfeld(er) Enabling and Novel Technologies
Genetics and Epidemiology
PSP-Element(e) G-503700-001
G-505600-003
PubMed ID 28922389
DOI 10.1371/journal.pone.0184721
WOS ID WOS:000411059300024
Scopus ID 85029597764
Erfassungsdatum 2017-09-26
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