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The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease.
Mol. Cell. Pediatr. 4:11 (2017)
The development of neonatal chronic lung disease (nCLD), i.e., bronchopulmonary dysplasia (BPD) in preterm infants, significantly determines long-term outcome in this patient population. Risk factors include mechanical ventilation and oxygen toxicity impacting on the immature lung resulting in impaired alveolarization and vascularization. Disease development is characterized by inflammation, extracellular matrix remodeling, and apoptosis, closely intertwined with the dysregulation of growth factor signaling. This review focuses on the causes and consequences of altered signaling in central pathways like transforming growth factor (TGF), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) driving these above indicated processes, i.e., inflammation, matrix remodeling, and vascular development. We emphasize the shared and distinct role of these pathways as well as their interconnection in disease initiation and progression, generating important knowledge for the development of future treatment strategies.
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Scopus SNIP
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Anmerkungen
Besondere Publikation
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Sprache
englisch
Veröffentlichungsjahr
2017
HGF-Berichtsjahr
2017
ISSN (print) / ISBN
2194-7791
Zeitschrift
Molecular and Cellular Pediatrics
Quellenangaben
Band: 4,
Heft: 1,
Artikelnummer: 11
Verlag
Springer
Verlagsort
Berlin ; Heidelberg [u.a.]
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Lung Health and Immunity (LHI)
POF Topic(s)
30202 - Environmental Health
80000 - German Center for Lung Research
30503 - Chronic Diseases of the Lung and Allergies
80000 - German Center for Lung Research
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er)
Lung Research
PSP-Element(e)
G-552100-001
G-501800-805
G-508700-004
G-501800-805
G-508700-004
Scopus ID
105005123116
PubMed ID
29116547
Erfassungsdatum
2017-11-16