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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Combining traditional dietary assessment methods with novel metabolomics techniques: Present efforts by the Food Biomarker Alliance.
Proc. Nutr. Soc. 76, 619-627 (2017)
© 2017 The Authors. FFQ, food diaries and 24 h recall methods represent the most commonly used dietary assessment tools in human studies on nutrition and health, but food intake biomarkers are assumed to provide a more objective reflection of intake. Unfortunately, very few of these biomarkers are sufficiently validated. This review provides an overview of food intake biomarker research and highlights present research efforts of the Joint Programming Initiative 'A Healthy Diet for a Healthy Life' (JPI-HDHL) Food Biomarkers Alliance (FoodBAll). In order to identify novel food intake biomarkers, the focus is on new food metabolomics techniques that allow the quantification of up to thousands of metabolites simultaneously, which may be applied in intervention and observational studies. As biomarkers are often influenced by various other factors than the food under investigation, FoodBAll developed a food intake biomarker quality and validity score aiming to assist the systematic evaluation of novel biomarkers. Moreover, to evaluate the applicability of nutritional biomarkers, studies are presently also focusing on associations between food intake biomarkers and diet-related disease risk. In order to be successful in these metabolomics studies, knowledge about available electronic metabolomics resources is necessary and further developments of these resources are essential. Ultimately, present efforts in this research area aim to advance quality control of traditional dietary assessment methods, advance compliance evaluation in nutritional intervention studies, and increase the significance of observational studies by investigating associations between nutrition and health.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Dietary Assessment ; Food Intake Biomarkers ; Food Metabolome ; Metabolomics; Spectrometry-based Metabolomics; Nuclear-magnetic-resonance; Dried Blood Spot; Mass-spectrometry; Fish Consumption; Meat Consumption; Vegetable Intake; Healthy Humans; Energy-intake; Fatty-acids
ISSN (print) / ISBN
0029-6651
e-ISSN
1475-2719
Zeitschrift
The proceedings of the Nutrition Society
Quellenangaben
Band: 76,
Heft: 4,
Seiten: 619-627
Verlag
Cambridge Univ. Press
Verlagsort
London [u.a.]
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology II (EPI2)