PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Steck, A.K.* ; Larsson, H.E.* ; Liu, X.* ; Veijola, R.* ; Toppari, J.* ; Hagopian, W.A.* ; Haller, M.J.* ; Ahmed, S.* ; Akolkar, B.* ; Lernmark, A.* ; Rewers, M.J.* ; Krischer, J.P.* ; TEDDY Study Group (Ziegler, A.-G. ; Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Janz, N. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Scholz, M. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Wendel, L. ; Winkler, C.)

Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls.

Pediatr. Diabetes 18, 794-802 (2017)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
ObjectiveTo explore whether children diagnosed with type 1 diabetes during islet autoantibody surveillance through The Environmental Determinants of Diabetes in the Young (TEDDY) study retain greater islet function than children diagnosed through the community. Methods TEDDY children identified at birth with high-risk human leukocyte antigen and followed every 3months until diabetes diagnosis were compared to age-matched children diagnosed with diabetes in the community. Both participated in long-term follow up after diagnosis. Hemoglobin A1c (HbA1c) and mixed meal tolerance test were performed within 1month of diabetes onset, then at 3, 6, and 12months, and biannually thereafter. ResultsComparison of 43 TEDDY and 43 paired control children showed that TEDDY children often had no symptoms (58%) at diagnosis and none had diabetic ketoacidosis (DKA) compared with 98% with diabetes symptoms and 14% DKA in the controls (P<0.001 and P=0.03, respectively). At diagnosis, mean HbA1c was lower in TEDDY (6.8%, 51mmol/mol) than control (10.5%, 91mmol/mol) children (P<0.0001). TEDDY children had significantly higher area under the curve and peak C-peptide values than the community controls throughout the first year postdiagnosis. Total insulin dose and insulin dose-adjusted A1c were lower throughout the first year postdiagnosis for TEDDY compared with control children. ConclusionsHigher C-peptide levels in TEDDY vs community-diagnosed children persist for at least 12months following diabetes onset and appear to represent a shift in the disease process of about 6months. Symptom-free diagnosis, reduction of DKA, and the potential for immune intervention with increased baseline C-peptide may portend additional long-term benefits of early diagnosis.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.267
1.594
18
21
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Hba1c ; Pediatric Diabetes ; Preservation Of C-peptide ; Prospective Study ; Type 1 Diabetes; Glutamic-acid Decarboxylase; C-peptide; Environmental Determinants; Islet Autoantibodies; Complications Trial; Partial Remission; Type-1; Ketoacidosis; Onset; Young
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1399-543X
e-ISSN 1399-5448
Zeitschrift Pediatric Diabetes
Quellenangaben Band: 18, Heft: 8, Seiten: 794-802 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502100-001
G-501900-021
DOI 10.1111/pedi.12485
WOS ID WOS:000415012600017
Scopus ID 85011604859
PubMed ID 28127835
Erfassungsdatum 2017-11-28
[➜Korrektur melden]