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Schöllnberger, H. ; Eidemüller, M. ; Cullings, H.M.* ; Simonetto, C. ; Neff, F.* ; Kaiser, J.C.

Dose-responses for mortality from cerebrovascular and heart diseases in atomic bomb survivors: 1950-2003.

Radiat. Environ. Biophys. 57, 17-29 (2018)
Forschungsdaten DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The scientific community faces important discussions on the validity of the linear no-threshold (LNT) model for radiation-associated cardiovascular diseases at low and moderate doses. In the present study, mortalities from cerebrovascular diseases (CeVD) and heart diseases from the latest data on atomic bomb survivors were analyzed. The analysis was performed with several radio-biologically motivated linear and nonlinear dose-response models. For each detrimental health outcome one set of models was identified that all fitted the data about equally well. This set was used for multi-model inference (MMI), a statistical method of superposing different models to allow risk estimates to be based on several plausible dose-response models rather than just relying on a single model of choice. MMI provides a more accurate determination of the dose response and a more comprehensive characterization of uncertainties. It was found that for CeVD, the dose-response curve from MMI is located below the linear no-threshold model at low and medium doses (0-1.4 Gy). At higher doses MMI predicts a higher risk compared to the LNT model. A sublinear dose-response was also found for heart diseases (0-3 Gy). The analyses provide no conclusive answer to the question whether there is a radiation risk below 0.75 Gy for CeVD and 2.6 Gy for heart diseases. MMI suggests that the dose-response curves for CeVD and heart diseases in the Lifespan Study are sublinear at low and moderate doses. This has relevance for radiotherapy treatment planning and for international radiation protection practices in general.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Ionizing Radiation ; Cardiovascular Diseases ; Atomic Bomb Survivors ; Risk Assessment ; Linear No-threshold Model ; Nonlinear Dose-response; Level Ionizing-radiation; Multimodel Inference; Apoe(-/-) Mice; Circulatory Diseases; Cardiovascular-disease; Nuclear Workers; Model Selection; Breast-cancer; Solid Cancer; Life-span
Sprache
Veröffentlichungsjahr 2018
Prepublished im Jahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Zeitschrift Radiation and Environmental Biophysics
Quellenangaben Band: 57, Heft: 1, Seiten: 17-29 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Protection (ISS)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501100-004
G-501100-005
DOI 10.1007/s00411-017-0722-5
WOS ID WOS:000425287100003
Scopus ID 85037619879
PubMed ID 29222678
Erfassungsdatum 2017-12-27
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