Dokumente im Korb
Helmholtz Zentrum München
|
Impressum
PuSH - Publikationsserver des Helmholtz Zentrums München
Navigation
Startseite
English
Recherche
Erweiterte Suche
Durchblättern nach ...
... Zeitschriften
... Publikationstypen
... Forschungsdaten
... Erscheinungsjahr
Publikationen im Überblick
Hilfe & Kontakt
Ansprechpartner
Hilfe
Datenschutz
Wang, C.* ; Edilova, M.I.* ; Wagar, L.E.* ; Mujib, S.* ; Singer, M.* ; Bernard, N.F.* ; Croughs, T.* ; Lederman, M.M.* ; Sereti, I.* ; Fischl, M.A.* ;
Kremmer, E.
; Ostrowski, M.A.* ; Routy, J.P.* ; Watts, T.H.*
Effect of IL-7 Therapy on Phospho-Ribosomal Protein S6 and TRAF1 Expression in HIV-Specific CD8 T Cells in Patients Receiving Antiretroviral Therapy.
J. Immunol.
200
, 558-564 (2018)
Verlagsversion
Forschungsdaten
DOI
PMC
Open Access Green
möglich sobald Postprint bei der ZB eingereicht worden ist.
Abstract
Metriken
Zusatzinfos
Copyright © 2018 by The American Association of Immunologists, Inc. IL-7 therapy has been evaluated in patients who do not regain normal CD4 T cell counts after virologically successful antiretroviral therapy. IL-7 increases total circulating CD4 and CD8 T cell counts; however, its effect on HIV-specific CD8 T cells has not been fully examined. TRAF1, a prosurvival signaling adaptor required for 4-1BB-mediated costimulation, is lost from chronically stimulated virus-specific CD8 T cells with progression of HIV infection in humans and during chronic lymphocytic choriomeningitis infection in mice. Previous results showed that IL-7 can restore TRAF1 expression in virus-specific CD8 T cells in mice, rendering them sensitive to anti-4-1BB agonist therapy. In this article, we show that IL-7 therapy in humans increases the number of circulating HIV-specific CD8 T cells. For a subset of patients, we also observed an increased frequency of TRAF1+HIV-specific CD8 T cells 10 wk after completion of IL-7 treatment. IL-7 treatment increased levels of phospho-ribosomal protein S6 in HIV-specific CD8 T cells, suggesting increased activation of the metabolic checkpoint kinase mTORC1. Thus, IL-7 therapy in antiretroviral therapy-treated patients induces sustained changes in the number and phenotype of HIV-specific T cells.
Altmetric
Weitere Metriken?
[➜Einloggen]
Tags
Anmerkungen
Besondere Publikation
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Korrespondenzautor
Schlagwörter
Recombinant Human Interleukin-7; Chronic Viral-infection; Bim Modulation; In-vivo; Survival; Mtor; Differentiation; Phosphorylation; Persistence; Multicenter
Keywords plus
ISSN (print) / ISBN
0022-1767
e-ISSN
1550-6606
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Zeitschrift
Journal of Immunology
Quellenangaben
Band: 200,
Heft: 2,
Seiten: 558-564
Artikelnummer: ,
Supplement: ,
Reihe
Verlag
American Association of Immunologists
Verlagsort
Bethesda
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Veröffentlichungsnummer
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
CF Monoclonal Antibodies (CF-MAB)
Förderungen