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Nunes, A. ; Pansare, V.J.* ; Bézière, N. ; Kolokithas-Ntoukas, A. ; Reber, J. ; Bruzek, M.* ; Anthony, J.* ; Prud´homme, R.K.* ; Ntziachristos, V.

Quenched hexacene optoacoustic nanoparticles.

J. Mater. Chem. B 6, 44-55 (2017)
Postprint Forschungsdaten DOI
Open Access Green
Optoacoustic (photoacoustic) imaging enables high-resolution optical imaging at depths well beyond optical microscopy, revolutionizing optical interrogation of tissues. Operation in the near-infrared (NIR) is nevertheless necessary to capitalize on the technology potential and reach depths of several centimeters. Using Flash NanoPrecipitation for highly-scalable single-step encapsulation of hydrophobic hexacene at self-quenching concentrations, we propose quenched fluorescence-dye nanoparticles as a potent alternative to NIR metal nanoparticles for strong optoacoustic signal generation. Comprehensive hexacene-based nanoparticle characterization was based on a 5-step approach that examined the physicochemical features (Step 1), optoacoustic signal generation (Step 2), stability (Step 3), biocompatibility (Step 4) and spectral sensitivity (Step 5). Using this characterization framework we showcase the discovery of two nanoparticle formulations, QH2-50 nm and QH2-100 nm that attain superior stability characteristics and optimal optoacoustic properties compared to gold standards commonly employed for near-infrared optoacoustics. We discuss encapsulation and self-quenching (ESQ) of organic dyes as a promising strategy to generate optimal optoacoustic particles.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Substituted Pentacene Derivatives; Carbon Nanotube Toxicity; Confined Impinging Jets; In-vivo; Flash Nanoprecipitation; Gold Nanoparticles; Fluorescent Nanoparticles; Protected Nanoparticles; Thermal-stability; Organic Actives
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 2050-750X
e-ISSN 2050-7518
Zeitschrift Journal of Materials Chemistry B: Materials for Biology and Medicine
Quellenangaben Band: 6, Heft: 1, Seiten: 44-55 Artikelnummer: , Supplement: ,
Verlag Royal Society of Chemistry (RSC)
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
DOI 10.1039/C7TB02633A
WOS ID WOS:000418379700004
Scopus ID 85038948757
Erfassungsdatum 2017-12-11
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