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Knoop, J. ; Gavrisan, A. ; Kuehn, D.* ; Reinhardt, J.M.* ; Heinrich, M. ; Hippich, M. ; Eugster, A.* ; Ockert, C.* ; Ziegler, A.-G. ; Bonifacio, E.*

GM-CSF producing autoreactive CD4(+) T cells in type 1 diabetes.

Clin. Immunol. 188, 23-30 (2017)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The phenotype of autoreactive T cells in type 1 diabetes is described as Th1, Th17 and/or Th21, but is largely uncharacterized. We combined multi-parameter cytokine profiling and proliferation, and identified GM-CSF producing cells as a component of the response to beta cell autoantigens proinsulin and GAD65. Overall cytokine profiles of CD4(+) T cell were not altered in type 1 diabetes. In contrast, patients with recent onset type 1 diabetes had increased frequencies of proinsulin-responsive CD4(+) CD45RA(-) T cells producing GM-CSF (p = 0.002), IFN gamma (p = 0.004), IL-17A (p = 0.008), IL-21 (p = 0.011), and IL-22 (p = 0.007), and GAD65-responsive CD4(+) CD45RA(-) T cells producing IL-21 (p = 0.039). CD4(+) T cells with a GM-CSF+IFN gamma-IL-17A(-)IL-21(-)IL-22(-) phenotype were increased in patients for responses to both proinsulin (p = 0.006) and GAD65 (p = 0.037). GM-CSF producing T cells are a novel phenotype in the repertoire of T helper cells in type 1 diabetes and consolidate a Th1/Th17 pro-inflammatory pathogenesis in the disease. (C) 2017 The Authors. Published by Elsevier Inc.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Type 1 Diabetes ; Gm-csf ; Cytokines ; Memory Cd4(+) T Cell ; Th1 Immunity ; Autoreactive T Cells; Recent-onset; Responses; Proinsulin; Phenotype; Children; Donors; Gamma
ISSN (print) / ISBN 1521-6616
e-ISSN 1521-7035
Zeitschrift Clinical Immunology
Quellenangaben Band: 188, Heft: , Seiten: 23-30 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort San Diego
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research Type 1 (IDF)