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Hoffmann, C.* ; Weigert, C.

Skeletal muscle as an endocrine organ: The role of myokines in exercise adaptations.

Cold Spring Harbor Perspect. Med. 7:a029793 (2017)
Verlagsversion DOI PMC
Free by publisher
Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions produced in skeletal muscle, termedmyokines. Based on the current state of knowledge, the major physiological function of myokines is to protect the functionality and to enhance the exercise capacity of skeletal muscle. Myokines control adaptive processes in skeletal muscle by acting as paracrine regulators of fuel oxidation, hypertrophy, angiogenesis, inflammatory processes, and regulation of the extracellular matrix. Endocrine functions attributed to myokines are involved in body weight regulation, low-grade inflammation, insulin sensitivity, suppression of tumor growth, and improvement of cognitive function. Muscle-derived regulatory RNAs and metabolites, as well as the design of modified myokines, are promising novel directions for treatment of chronic diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Activated Protein-kinase; Growth-factor-i; Interleukin-6 Messenger-rna; Human Myocyte Proliferation; Induced Insulin-resistance; Fatty-acid Oxidation; Diet-induced Obesity; Extracellular-matrix; Endurance Exercise; Igf-i
e-ISSN 2157-1422
Zeitschrift Cold Spring Harbor Perspectives in Medicine
Quellenangaben Band: 7, Heft: 11, Seiten: , Artikelnummer: a029793 Supplement: ,
Verlag Cold Spring Harbor Laboratory Press
Verlagsort Cold Spring Harbor
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)