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Schwarzenböck, C.* ; Schaffer, A.* ; Nößner, E. ; Nelson, P.J.* ; Huss, R.* ; Rieger, B.*

Fluorescent polyvinylphosphonate bioconjugates for selective cellular delivery.

Chem. Eur. J. 24, 2584-2587 (2018)
Postprint DOI PMC
Open Access Green
To date, many poly(ethylene glycol) (PEG) and poly(N-isopropylacrylamide) (PNIPAAm) biomolecule conjugates have been described, but they often show long response times, are not bio-inert, or lose function in biological fluids. Herein, we present a modular synthetic approach to generate polyvinylphosphonate biomolecule conjugates. These conjugates exhibit a sharp phase transition temperature even under physiological conditions where few other examples with this property have been described to date. Furthermore, it was feasible to add biological functions to the polymers via the conjugation step. The polyvinylphosphonate cholesterol constructs are attached to the cellular membrane and the folic acid anchored polymers are shuttled into the cells. This is an exceptional finding through a straightforward synthetic approach.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Delivery ; Fluorescent Polymer Bioconjugate ; Selective Cellular Targeting ; Thermoresponsive Polymer ; Thiol-ene Click Chemistry; Group-transfer Polymerization; Membrane Imaging Reagent; Serum-albumin; Cholesterol; Cancer; Cells; Nanoparticles; Polymersomes; Micelles; Tissues
ISSN (print) / ISBN 0947-6539
e-ISSN 1521-3765
Zeitschrift Chemistry - A European Journal
Quellenangaben Band: 24, Heft: 11, Seiten: 2584-2587 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Weinheim
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CF Immunoanalytics (IMA)