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Verkhratsky, A.* ; Trebak, M.* ; Perocchi, F. ; Khananshvili, D.* ; Sekler, I.*

Crosslink between calcium and sodium signalling.

Exp. Physiol. 103, 157-169 (2018)
Verlagsversion DOI PMC
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Transmembrane ionic gradients, which are an indispensable feature of life, are used for generation of cytosolic ionic signals that regulate a host of cellular functions. Intracellular signalling mediated by Ca2+ and Na+ is tightly linked through several molecular pathways that generate Ca2+ and Na+ fluxes and are in turn regulated by both ions. Transient receptor potential (TRP) channels bridge endoplasmic reticulum Ca2+ release with generation of Na+ and Ca2+ currents. The plasmalemmal Na+-Ca2+ exchanger (NCX) flickers between forward and reverse mode to co-ordinate the influx and efflux of both ions with membrane polarization and cytosolic ion concentrations. The mitochondrial calcium uniporter channel (MCU) and mitochondrial Na+-Ca2+ exchanger (NCLX) mediate Ca2+ entry into and release from this organelle and couple cytosolic Ca2+ and Na+ fluctuations with cellular energetics. Cellular Ca2+ and Na+ signalling controls numerous functional responses and, in the CNS, provides for fast regulation of astroglial homeostatic cascades that are crucial for maintenance of synaptic transmission.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Astrocytes ; Ca2+ Signalling ; Mitochondria ; Mitochondrial Calcium Uniporter ; Na+ Signalling ; Na+-ca2+ Exchanger ; Neuropathology ; Transient Receptor Potential Channels; Bergmann Glial-cells; Endothelial Barrier Function; Operated Ca2+ Entry; Na+/ca2+ Exchanger; Hippocampal Astrocytes; In-situ; Pathophysiological Conditions; Equilibrium Properties; Intracellular Sodium; Glutamate Transport
ISSN (print) / ISBN 0958-0670
e-ISSN 1469-445X
Zeitschrift Experimental Physiology
Quellenangaben Band: 103, Heft: 2, Seiten: 157-169 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)