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Verkhratsky, A.* ; Trebak, M.* ; Perocchi, F. ; Khananshvili, D.* ; Sekler, I.*

Crosslink between calcium and sodium signalling.

Exp. Physiol. 103, 157-169 (2018)
Verlagsversion DOI PMC
Open Access Gold
Transmembrane ionic gradients, which are an indispensable feature of life, are used for generation of cytosolic ionic signals that regulate a host of cellular functions. Intracellular signalling mediated by Ca2+ and Na+ is tightly linked through several molecular pathways that generate Ca2+ and Na+ fluxes and are in turn regulated by both ions. Transient receptor potential (TRP) channels bridge endoplasmic reticulum Ca2+ release with generation of Na+ and Ca2+ currents. The plasmalemmal Na+-Ca2+ exchanger (NCX) flickers between forward and reverse mode to co-ordinate the influx and efflux of both ions with membrane polarization and cytosolic ion concentrations. The mitochondrial calcium uniporter channel (MCU) and mitochondrial Na+-Ca2+ exchanger (NCLX) mediate Ca2+ entry into and release from this organelle and couple cytosolic Ca2+ and Na+ fluctuations with cellular energetics. Cellular Ca2+ and Na+ signalling controls numerous functional responses and, in the CNS, provides for fast regulation of astroglial homeostatic cascades that are crucial for maintenance of synaptic transmission.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Astrocytes ; Ca2+ Signalling ; Mitochondria ; Mitochondrial Calcium Uniporter ; Na+ Signalling ; Na+-ca2+ Exchanger ; Neuropathology ; Transient Receptor Potential Channels; Bergmann Glial-cells; Endothelial Barrier Function; Operated Ca2+ Entry; Na+/ca2+ Exchanger; Hippocampal Astrocytes; In-situ; Pathophysiological Conditions; Equilibrium Properties; Intracellular Sodium; Glutamate Transport
ISSN (print) / ISBN 0958-0670
e-ISSN 1469-445X
Zeitschrift Experimental Physiology
Quellenangaben Band: 103, Heft: 2, Seiten: 157-169 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)