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van Karnebeek, C.D.M.* ; Wortmann, S.B. ; Tarailo-Graovac, M.* ; Langeveld, M.* ; Ferreira, C.R.* ; van de Kamp, J.M.* ; Hollak, C.E.* ; Wasserman, W.W.* ; Waterham, H.R.* ; Wevers, R.A.* ; Haack, T.B.* ; Wanders, R.J.A.* ; Boycott, K.M.*

The role of the clinician in the multi-omics era: Are you ready?

J. Inherit. Metab. Dis. 41, 571-582 (2018)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Inherited Metabolic Disease ; Genomics ; Metabolomics ; Diagnosis ; Treatment ; Precision Medicine; Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
ISSN (print) / ISBN 0141-8955
e-ISSN 1573-2665
Zeitschrift Journal of Inherited Metabolic Disease
Quellenangaben Band: 41, Heft: 3, Seiten: 571-582 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)