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Storz, C.* ; Heber, S.D.* ; Rospleszcz, S. ; Machann, J. ; Sellner, S.* ; Nikolaou, K.* ; Lorbeer, R.* ; Gatidis, S.* ; Elser, S.* ; Peters, A. ; Schlett, C.L.* ; Bamberg, F.*

The role of visceral and subcutaneous adipose tissue measurements and their ratio by magnetic resonance imaging in subjects with prediabetes, diabetes and healthy controls from a general population without cardiovascular disease.

Br. J. Radiol. 91 (2018)
Verlagsversion Postprint DOI PMC
Open Access Green
Objective: To study the relationship of area- and volumetric-based visceral and subcutaneous adipose tissue (VAT and SAT) by MRI and their ratio in subjects with impaired glucose metabolism from the general population.Methods: Subjects from a population-based cohort with established prediabetes, diabetes and healthy controls without prior cardiovascular diseases underwent 3 T MRI. VAT and SAT were assessed as total volume and area on a single slice, and their ratio (VAT/SAT) was calculated. Clinical covariates and cardiovascular risk factors, such as hypertension and glycemic state were assessed in standardized fashion, Univariate and adjusted analyses were conducted.Results: Among 384 subjects (age: 56.2 +/- 9.2 years, 581% male) with complete MRI data available, volumetric and single-slice VAT, SAT and VAT/SAT ratio were strongly correlated (all >r = 0.89), Similarly, VAT/SAT(volum)(e). ratio was strongly correlated with VAT(volume), but not with SAT (r = 0.72 and r = -0.21, respectively). Significant higher levels of VAT, SAT and VAT/SAT ratio were found in subjects with impaired glucose metabolism (all p <= 0.01). After adjustment for potential cardiovascular confounders, VAT(volume) and VAT/SAT(volume) ratio remained significantly higher in subjects with impaired glucose metabolism (VAT(volume) = 6.9 +/- 2.5 I and 3.4 +/- 2.3 I; VAT/SAT(volume) ratio = 0.82 +/- 0.34 I and 0.49 +/- 0,29 I in patients with diabetes and controls, respectively, all p < 0.02), whereas the association for SAT(volume) attenuated. Additionally, there was a decreasing effect of glycemic status on VAT/SAT(volume) ratio with increasing body mass index and waist circumference (p < 0.05).Conclusions: VAT(volume) and VAT/SAT volume ratio are associated with impaired glucose metabolism, independent of cardiovascular risk factors or MRI-based quantification technique, with a decreasing effect of VAT/SAT(volume) ratio in obese subjects.Advances in knowledge: Quantification of VAT(volume) and VAT/SAT(volume). ratio by MRI represents a reproducable biomarker associated with cardiometabolic risk factors in subjects with impaired glucose metabolism, while the association of VAT/SAT(volume) ratio with glycemic state is attenuated in obese subjects.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Metabolic Risk-factors; Abdominal Fat; Cardiometabolic Risk; Insulin Sensitivity; Computed-tomography; Large Cohort; Mri; Compartments; Association; Obesity
ISSN (print) / ISBN 0007-1285
e-ISSN 1748-880X
Zeitschrift British Journal of Radiology, The
Quellenangaben Band: 91, Heft: 1089 Seiten: , Artikelnummer: , Supplement: ,
Verlag British Institute of Radiology N.S
Verlagsort 36 Portland Place, London W1n 4at, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Institute of Diabetes Research and Metabolic Diseases (IDM)