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van der Vorst, E.P.C.* ; de Jong, R.J. ; Donners, M.M.P.C.*

Message in a microbottle: Modulation of vascular inflammation and atherosclerosis by extracellular vesicles.

Front. Cardiovasc. Med. 5:2 (2018)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Extracellular vesicles (EVs) have emerged as a novel intercellular communication system. By carrying bioactive lipids, miRNAs and proteins they can modulate target cell functions and phenotype. Circulating levels of EVs are increased in inflammatory conditions, e.g., cardiovascular disease patients, and their functional contribution to atherosclerotic disease development is currently heavily studied. This review will describe how EVs can modulate vascular cell functions relevant to vascular inflammation and atherosclerosis, particularly highlighting the role of EV-associated proteolytic activity and effector proteins involved. Furthermore, we will discuss key questions and challenges, especially for EV-based therapeutics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Atherosclerosis ; Challenges ; Extracellular Vesicles ; Proteolytic Activity ; Vascular Inflammation
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 2297-055X
e-ISSN 2297-055X
Zeitschrift Frontiers in Cardiovascular Medicine
Quellenangaben Band: 5, Heft: , Seiten: , Artikelnummer: 2 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Allergy
PSP-Element(e) G-505491-001
DOI 10.3389/fcvm.2018.00002
PubMed ID 29404342
Erfassungsdatum 2018-03-16
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