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Hartl, D.* ; Tirouvanziam, R.* ; Laval, J.* ; Greene, C.M.* ; Habiel, D.M.* ; Sharma, L.* ; Yildirim, A.Ö. ; Dela Cruz, C.S.* ; Hogaboam, C.M.*

Innate immunity of the lung: From basic mechanisms to translational medicine.

J. Innate Immun. 10, 487-501 (2018)
Verlagsversion Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune system also has to cope with harmful microbial or sterile threats and react rapidly to protect the host at this intimate barrier zone. The airways are endowed with a broad armamentarium of cellular and humoral host defense mechanisms, most of which belong to the innate arm of the immune system. The complex interplay between resident and infiltrating immune cells and secreted innate immune proteins shapes the outcome of host-pathogen, host-allergen, and host-particle interactions within the mucosal airway compartment. Here, we summarize and discuss recent findings on pulmonary innate immunity and highlight key pathways relevant for biomarker and therapeutic targeting strategies for acute and chronic diseases of the respiratory tract. (c) 2018 S. Karger AG, Basel
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Lung ; Immunity ; Immune Cells ; Neutrophils ; Macrophages ; Innate Lymphoid Cells ; Epithelial Cells; Invariant T-cells; Neutrophil Extracellular Traps; Obstructive Pulmonary-disease; Human Chitotriosidase Gene; Cystic-fibrosis Airways; Vitamin-b Metabolites; Sweet Taste Receptors; Lymphoid-cells; Mait Cells; Cxcr2 Antagonist
ISSN (print) / ISBN 1662-811X
e-ISSN 1662-8128
Zeitschrift Journal of Innate Immunity
Quellenangaben Band: 10, Heft: 5-6, Seiten: 487-501 Artikelnummer: , Supplement: ,
Verlag Karger
Verlagsort Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Biology (LHI)