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Wagner, C.J.* ; Dintsios, C.M.* ; Metzger, F.G.* ; L'hoest, H.* ; Marschall, U.* ; Stollenwerk, B. ; Stock, S.*

Longterm persistence and nonrecurrence of depression treatment in Germany: A four-year retrospective follow-up using linked claims data.

Int. J. Methods Psychiatr. Res. 27:e1607 (2018)
Postprint DOI PMC
Open Access Green
Objectives: To measure persistence and nonrecurrence of depression treatment and investigate potential risk factors. Methods: We retrospectively observed a closed cohort of insurees with new-onset depression treatment in 2007 and without most psychiatric comorbidity for 16 quarters (plus one to ascertain discontinuation). We linked inpatient/outpatient/drug-data per person and quarter. Person-quarters containing specified depression services were classified as depression-treatment-person-quarters (DTPQ). We defined longterm-DTPQ-persistence as 16 + 1 continuous DTPQ and longterm-DTPQ-nonrecurrence as 12 continuous quarters without DTPQ and used multivariate logistic regression to explore associations with these outcomes. Results: Within first 16 quarters, 28,348 patients' first period (total time) persisted for a mean/median 5.4/3 (8.7/8) quarters. Fourteen percent had longterm-DTPQ-persistence, associated (p <.05) with baseline hospital (odds ratio, OR = 1.80), psychotherapy/specialist-interview and antidepressants (OR = 1.81), age (years, OR = 1.03), unemployment (OR = 1.21), retirement (OR = 1.31), and insured as a dependent (OR = 1.32). Thirty-four percent had longterm-DTPQ-nonrecurrence, associated with psychotherapy/specialist-interview (OR = 1.40), antidepressants (OR = 0.54), female sex (OR = 0.84), age (years, OR = 0.99), retirement (OR = 1.18), and insured as a dependent (OR = 0.88). Women differed for episodic and not chronic treatment. Conclusion: Treatment measures compared to survey's symptoms measures. We suggest further research on “treatment-free-time.” Antidepressants(−) and psychotherapy/specialist-interview(+) were significantly associated with longterm-DTPQ-nonrecurrence. This was presumably moderated by possible short-time/low-dosage antidepressants use(−) and selective therapy assignment(+). Sample selectivity limited data misclassification.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Depressive Disorder ; Longitudinal Studies ; Psychotherapy ; Recurrence ; Risk Factors; Cell-line Thp-1; In-vitro; Hacat Keratinocytes; Alkaloid Berberine; Dendritic Cells; Injury; Skin; Sensitization; Expression; Toxicity
ISSN (print) / ISBN 1049-8931
e-ISSN 1557-0657
Zeitschrift International Journal of Methods in Psychiatric Research
Quellenangaben Band: 27, Heft: 2, Seiten: , Artikelnummer: e1607 Supplement: ,
Verlag Wiley
Verlagsort Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Health Economics and Health Care Management (IGM)