Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
DOI
PMC
 |
|
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Animal models of obesity and diabetes mellitus.
Nat. Rev. Endocrinol. 14, 140-162 (2018)
More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
High-fat-diet; Induced Insulin-resistance; Hepatic Glucose-uptake; Zebrafish Danio-rerio; Body-mass Index; Beta-cell Failure; Ob-ob Mice; Brown Adipose-tissue; Leptin Receptor Lepr; Inhibits Food-intake
ISSN (print) / ISBN
1759-5029
e-ISSN
1759-5037
Zeitschrift
Nature Reviews - Endocrinology
Quellenangaben
Band: 14,
Heft: 3,
Seiten: 140-162
Verlag
Nature Publishing Group
Verlagsort
New York, NY
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed