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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Alleviation of trigeminal nociception using p75 neurotrophin receptor targeted lentiviral interference therapy.
Neurotherapeutics 15, 489-499 (2018)
Verlagsversion
Forschungsdaten
DOI
PMC
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
P75ntr ; Capsaicin ; Trpv1 ; Neuropathic Pain ; Neurotherapeutics; Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
ISSN (print) / ISBN
1933-7213
e-ISSN
1878-7479
Zeitschrift
Neurotherapeutics
Quellenangaben
Band: 15,
Heft: 2,
Seiten: 489-499
Verlag
Springer
Verlagsort
New York, NY
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed