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Chou, K.L.* ; Stacy, M.* ; Simuni, T.* ; Miyasaki, J.* ; Oertel, W.H. ; Sethi, K.* ; Fernandez, H.H.* ; Stocchi, F.*

The spectrum of "off" in Parkinson's disease: What have we learned over 40 years?

Parkinsonism Relat. Disord. 51, 9-16 (2018)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The terms "on" and "off" were used by Marsden and his contemporaries over 40 years ago to describe times when Parkinson's disease patients experienced good motor function ("on") and immobility ("off"). Yet there remains no published consensus definition of "off", leading clinicians and patients to develop individualized impressions of "off" determinations. In this paper, we first discuss the evolution of the terminology and understanding of "off" states since Marsden's time, which now include non-motor as well as motor symptoms. We then review pathophysiology and risk factors for the development of "off' states as well as tools to detect the "off" state, before proposing a practical definition of "off" for consideration. A common, practical definition of the "off" state could improve clinical recognition of "off' symptoms and lead to significant benefit for patients.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Off ; Wearing Off ; Motor Fluctuations ; Motor Complications ; Non-motor Fluctuations ; Parkinson's Disease; Duodenal Levodopa Infusion; Nonmotor Wearing-off; Motor Fluctuations; L-dopa; Extracellular Dopamine; Patient Questionnaire; Cognitive Impairment; Clinical-features; Amino-acids; Therapy
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 1353-8020
e-ISSN 1873-5126
Zeitschrift Parkinsonism & Related Disorders
Quellenangaben Band: 51, Heft: , Seiten: 9-16 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Neurogenomics (ING)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503200-001
DOI 10.1016/j.parkreldis.2018.02.001
WOS ID WOS:000438660600003
Scopus ID 85042008245
PubMed ID 29456046
Erfassungsdatum 2018-06-07
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